Health Research Program

Focus Area: Newborn Health

Resource
Despite large investments to prevent mother-to-child-transmission (PMTCT), pediatric HIV elimination goals are not on track in many countries. The Systems Analysis and Improvement Approach (SAIA) study was a cluster-randomized trial to test whether a package of systems engineering tools could strengthen PMTCT programs. The authors sought to (1) define core and adaptable components of the SAIA intervention, and (2) explain the heterogeneity in SAIA’s success between facilities.
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The Ponya Mtoto project in Kenya aims to assist in reducing the number of infant deaths due to possible serious bacterial infection (PSBI), or sepsis, by revising national Integrated Management of Childhood Illness (IMCI) guidelines. These new guidelines are being implemented as part of a strengthened program of postnatal and young infant care.
Resource
The recommended management for neonates with a possible serious bacterial infection (PSBI) is hospitalisation and treatment with intravenous antibiotics, such as ampicillin plus gentamicin. However, hospitalisation is often not feasible for neonates in low‐ and middle‐income countries (LMICs). Therefore, alternative options for the management of neonatal PSBI in LMICs needs to be evaluated.