Want to Learn More About Managing Young Infant Sepsis?

Photo Credit: Assist Project employed a quality improvement methodology and saw a 13% reduction in neonatal mortality. AIIMS Hospital. Credit: Amy Fowler/USAID
Join our Community of Practice to learn more about managing young infant sepsis

Possible Serious Bacterial Infections (PSBI)

One area the Health Research Program is focusing on is management of Possible Serious Bacterial Infections (PSBI) or young infant sepsis, when referral is not possible.

Sepsis accounts for 23 percent of newborn deaths in developing countries.1 The Health Research Program’s efforts around management of PSBI at the facility level illustrate the research-to-use process. In previous years, the Health Research Program helped accelerate global policy change and country level action for the treatment of PSBI in newborns. This was accomplished through convening stakeholders to support clinical trials for simpler treatment regimens and conducting research to understand how to reach newborns outside of clinics in low-resource settings. Based on these studies, WHO released new guidelines on the treatment of PSBI in 2015 and convened meetings in several countries to orient policy makers and select local implementation sites. With funding from Bill and Melinda Gates Foundation, WHO established technical support units in seven countries in Africa and Asia.

Building on these efforts, the Health Research Program issued an Addendum to the Global Health Broad Agency Announcement in August 2016, soliciting Expressions of Interest for implementation research to support introduction of of the simplified regimen in real-world settings. Awards are anticipated in the summer of 2017. Further information about our achievements in expanding coverage of PSBI treatment can be found on our Impact page

Community of Practice (CoP)

We define a CoP as “groups of people who share a concern or passion for something they do and learn how to do it better as they interact regularly.” These groups facilitate the collective pursuit of a shared interest through relationship building, learning and information sharing about a specific practice area or need. They also stimulate dialogue, capture and diffuse existing knowledge, support collaboration, organize members around purposeful action, generate new knowledge and help to connect people who might not ordinarily interact. Given these features, CoPs are uniquely positioned to help drive the research-to-use process by supporting stakeholder engagement, knowledge management, research translation, and research dissemination.


This CoP aims to foster technical exchange, collaboration, learning, capacity building and resource mobilization.


Provide a forum to enable information sharing (e.g., research findings, experiences, lessons learned, best practices) and problem-solving relevant to managing possible serious bacterial infections (PSBI) implementation and management

  • Spark dialogue about PSBI management, implementation research, translation of PSBI research and newborn health
  • Promote learning about PSBI management and implementation research
  • Encourage collaboration among PSBI stakeholder groups in different countries, regions and worldwide
  • Build country, regional and global capacity in all aspects of PSBI management, implementation and research
  • Develop, facilitate and mobilize resources for implementation research and PSBI
  • Cultivate champions of implementation research and research translation related to PSBI
  • Facilitate connections between global experts who might not otherwise interact

To join, click here.

1Liu L, Oza S, Hogan D, et. al. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015 Jan 31;385(9966):430-40. Figure 1 Source: http://www.who.int/maternal_child_adolescent/topics/child/mortality/en/